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  • 生命科学学院学术预告

    发布日期:2020-01-03访问次数: 字号:

    1、报告题目:Bioproduction in the algal chloroplast

    时间:2020年16日周一 上午8:30


    报告人:Prof. Saul Purton,Department of Structural & Molecular Biology, University College London

           报告摘要:Microalgae have significant potential as light-driven cell factories for the synthesis of a wide range of bioproducts. These include bioactive metabolites, high-value pigments, speciality enzymes, therapeutic proteins, biopolymers and RNA-based anti-viral agents. The genetic engineering of algae is most advanced for the model species Chlamydomonas reinhardtii, with well-established methods for manipulating both the nuclear and chloroplast genomes. The latter is particularly attractive as a site for insertion of foreign genes for a number of reasons: i) genes can be targeted to precise loci; ii) stable, high level expression can be achieved; iii) the small, low complexity genome is particularly suited to synthetic biology (synbio) approaches that allow rapid, standardised and predictive strain engineering; iv) the organelle is the site of numerous biosynthetic pathways and therefore represents the obvious ‘chassis on which to bolt new metabolic pathways that divert the carbon fixed by photosynthesis into novel compounds. I will present our recent progress on the development of synbio tools for genetic engineering of the chloroplast of C. reinhardtii, including a simple one-pot method for DNA assembly and selection methods that avoid the use of antibiotic-based markers. Our tools also include design strategies for biocontainment of transgenes, and their high-level and inducible expression, together with a method for low-cost algal cultivation in non-sterilised media. I will give examples of applications in the field of therapeutic proteins including the production of anti-bacterial enzymes that target major human pathogens, and bio-encapsulated vaccines for oral delivery in the aquaculture industry.


    时间:2020年16日周一 上午10:00


    报告人:刘进 研究员

           刘进,博士,北京大学工学院研究员,能源与资源工程系PI,食品与生物资源工程研究所PI。2003年和2005年于中山大学分别获得理学学士和理学硕士学位,2010年于香港大学获得理学博士学位。随后分别于美国Arizona State UniversityUniversity of Maryland从事博士后和助理研究员工作。2015年加入北京大学工学院,担任微藻生物技术创新课题组负责人,致力于通过交叉学科前沿科学技术开展藻类资源的基础及应用研究。曾入选国家青年千人计划、博雅青年学者等。目前已在SCI知名期刊(Molecular Plant, Plant Journal, Biotechnology for Biofuels, Metabolic Engineering, Food Chemistry, Applied Microbiology and Biotechnology等)上发表学术论文50多篇(其中2篇为封面文章),ElsevierWiley-Blackwell等国际知名出版社发表专著章节8篇,主编专著1部,主持国家重点研发计划课题、自然科学基金面上项目等多项项目。主要研究兴趣:油脂代谢、类胡萝卜素生物发生、藻类合成生物学。


    作者:生命科学学院 编辑:宣传部

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